Source: http://the-gadgeteer.com/2012/02/28/try-a-taste-of-fxi-cotton-candy/
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Wednesday, February 29, 2012
Try a Taste of FXI Cotton Candy
We first reported a prototype of the FXI Cotton Candy in November 2011, and a new updated version is now available for pre-order for $199 with limited availability in March 2012. As a quick reminder, the Cotton Candy is a self contained USB memory stick sized computer device that allows users to connect to personal [...]
SimCity 5 Confirmed in Games Magazine | Video Game News ...
Posted by Declan Burrowes on Wednesday, February 29, 2012 ? Leave a Comment?
According to a leak by German games magazine Gamestar, SimCity 5 is on route for a 2013 release.
The news comes after EA?s Senior Director of PR, Erik Reynolds, teased on Twitter that an important EA Maxis announcement is planned for next week?s GDC in San Francisco.
A translation of the magazine article suggests an improved graphics engine called ?Glassbox?, allowing players to oversee their civic creations from far above, or zoom down close enough to read individual shop signs. This level of detail continues to a minute level ? citizens can be seen meeting for lunch at caf?s and protesting unpopular mayoral legislation; the destitute will visibly take to sleeping on the streets or in parks, while their abandoned houses might become the hideouts of local criminals.
Curved roads and customisable buildings will make their premiere appearances.
Multiplayer is also touted as a major feature. Players will be able to share resources like water and power between cities. Though deeper interaction is probable, nothing concrete has yet been disclosed.
EA Maxis presented Gamestar with a gallery of concept art, stating that they would only release internal screenshots when they were absolutely sure the material was up to scratch:
Expect more details to come if next week?s GDC announcement does indeed confirm SimCity 5.
In the meantime, you can read more interesting speculation on the missing city-builder sequel here.
[Source: NeoGAF]
Source: http://bnbgaming.com/2012/02/29/simcity-5-confirmed-in-german-games-magazine/
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Tuesday, February 28, 2012
Higher death risk with sleeping pills
ScienceDaily (Feb. 27, 2012) ? People are relying on sleeping pills more than ever to get a good night's rest, but a new study by Scripps Clinic researchers links the medications to a 4.6 times higher risk of death and a significant increase in cancer cases among regular pill users.
The results, published?February 27 by the open-access online journal BMJ Open, cast a shadow over a growing segment of the pharmaceutical industry that expanded by 23 percent in the United States from 2006 to 2010 and generated about $2 billion in annual sales.
The possible health hazards
"What our study shows is that sleeping pills are hazardous to your health and might cause death by contributing to the occurrence of cancer, heart disease and other ailments," said author Daniel F. Kripke, MD, of the Viterbi Family Sleep Center at Scripps Health in San Diego.
The research is the first to show that eight of the most commonly used hypnotic drugs were associated with increased hazards of mortality and cancer, including the popularly prescribed medications zolpidem (known by the brand name Ambien) and temazepam (also known as Restoril), Dr. Kripke said. Those drugs had been thought to be safer than older hypnotics because of their shorter duration of action.
Study participants who took sleeping pills were matched with control patients of similar ages, gender and health who received no hypnotics in order to eliminate the possibility that other factors led to the results.
"We tried every practical strategy to make these associations go away, thinking that they could be due to use by people with more health problems, but no matter what we did the associations with higher mortality held," said co-author Robert D. Langer, MD, MPH, of the Jackson Hole Center for Preventive Medicine in Jackson, Wyoming.
Even among patients who were prescribed 1 to 18 sleeping pills per year, the risk of death was 3.6 times higher than among similar participants who did not take the medica-tions. The study looked at patients aged 18 years and older, and found the increased risk in all age groups.
Sleeping pills and cancer
Rates of new cancers were 35 percent higher among patients who were prescribed at least 132 hypnotic doses a year as compared with those who did not take the drugs.
Using data stored in an electronic medical record that has been in place for more than a decade, the researchers obtained information on almost 40,000 patients cared for by a large integrated health system in the northeastern United States.
The study included 10,531 sleeping pill users who were prescribed the medications for an average of 2.5 years and 23,674 control participants who were not prescribed the drugs. Information came from outpatient clinic visits conducted between Jan. 1, 2002, and Sept. 30, 2006.
"It is important to note that our results are based on observational data, so even though we did everything we could to ensure their validity, it's still possible that other factors explain the associations," said co-author Lawrence E. Kline, DO, who is medical director of the Viterbi Family Sleep Center. "We hope our work will spur additional research in this area using information from other populations."
Funding for the study came from the Scripps Health Foundation and other philanthropic sources.
Alternatives to medication
The BMJ Open report should prompt physicians to consider alternatives to hypnotic medications, Dr. Kline said.
Clinicians at the Viterbi Family Sleep Center focus on cognitive therapy that teaches patients to better understand the nature of sleep. For example, some people suffering from insomnia might require less than the eight hours of sleep commonly recommended for each night.
Patients also can benefit from practicing good sleeping habits and relaxation, as well as taking advantage of the body's natural clock, which is driven by the rising and setting of the sun, Dr. Kline said. "Understanding how to use the circadian rhythm is a very powerful tool that doesn't require a prescription," he said.
When insomnia results from emotional problems such as depression, doctors should treat the psychological disorder rather than prescribe sleeping pills that could prove to be harmful, Dr. Kripke said.
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The above story is reprinted from materials provided by Scripps Health.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Kripke DF, Langer RD, Kline LE. Hypnotics? association with mortality or cancer: a matched cohort study. BMJ Open, 2012;2:e000850 DOI: 10.1136/bmjopen-2012-000850
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/02/120227204830.htm
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Monday, February 27, 2012
Red meats and prostate cancer
Does meat consumption promote my risk or prostate cancer? Should I be vegetarian? Should I become vegan? This is a typical discussion I have with patients. There is plenty of reasons for the confusion. One day a vegan diet is promoted as the healthiest for disease-free longevity and the next week the Adkins diet, or more recently, the Paleolithic diet becomes more popular.
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What should you do if you are seeking prostate cancer protection?
Meat consumption is one of the most misunderstood topics as it relates to prostate cancer. The research is inconclusive at best. However, at this point I think simple carbohydrates (flour, cookies, pasta, breads etc) are most problematic. Wheat is also a problem as it is inflammatory and causes weight gain ? also not good for prostate cancer. I will have a more extensive blog post on the relationship between wheat, weight gain and prostate cancer soon.
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What does the research show?
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A prospective study of 1294 men with prostate cancer did not identify any association between increased meat consumption and prostate cancer recurrence or progression (Daley et al. 2010). There is a correlation, however, with consumption of well-done meats and increase in prostate cancer risk (Zheng et al. 2009). Well-done, charred meats produce Heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAH) ? carcinogenic chemicals formed from the cooking of muscle meats such as beef, pork, fowl, and fish. HCAs form when amino acids and creatine react at high cooking temperatures. Researchers have identified 17 different HCAs resulting from the cooking of meats that may pose human cancer risk.
When accessible, low-cooked temperature, grass-fed meat should be consumed by CaP patients due to their high carotenoid, vitamin E (alpha-tocopherol and gamma-tocopherol), glutathinone, conjugated linoleic acid (CLA) levels and low saturated fat content relative to grain-fed beef (Richman et al. 2010).
Cured meats should also be avoided as they contain nitrosamines because meats contain amines, and sodium nitrite, a source of nitrosating agents, is added to cured meats as a preservative.
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What is red meat?
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Red meat includes? animal products that are red before cooking: beef, ribs, pork, venison, lamb, sheep, etc.
Red meat does not refer to how well a piece of meat is cooked. Nor does it refer to its coloration after it has been cooked.
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10 things you should (and should not) do??
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- If your choice?s are between a high starch (simple carb) meal or a steak, choose the steak and have steamed broccoli cooked with olive oil, little salt and garlic. Don?t touch the bread. Leave the potatoes alone and run from the pasta. ? By the way, salt is not a ?bad food? and does not contribute to cancer or high blood pressure. Sea salt is healthier than table salt (sodium chloride). However, if you already suffer from high blood pressure then salt consumption may increase it even more. No extra salt if your are hypertensive.
- Cooking temperature is most important. Low heat and medium-rear is better than meats cooked in high heat and well-done. So far, there is more evidence that the problem with meats is the temperature they are cooked in? not the meats themselves.
- If possible (and make it possible when possible) eat grass-fed organic meats ? always low temperature cooking. Grass-fed, organic meats are low in saturated fat, high in CLA and anti-oxidants. The nutritional value is night and day compared to conventionally, high saturated-fat grain-raised beef. This website give you sources and valuable information of grass-feed meats
- Eat lots and lots of vegetables particularly cruciferous vegetables with your meats.
- Do not consume too much grain-fed beef. It?s a better alternative than a starchy meal but not necessarily that healthy. Save it for when you go out with some buddies to a steak house. Ask the waiter to add some rosemary to your steak. Rosemary inhibits the formation of HCA?s (Puangsombat et al. 2010) and also taste delicious.
- Deli sandwiches may be the worse. Think about it. What?s in a sandwich? Cold cuts (turkey, ham, pastrami) filled with nitrites. Nitrites may be associated with cancer formation. Cheese most likely from grain-fed cows. White flour in your roll or hero. Forget about having it on wheat bread ? that?s worse. Top it off with nutrient depleted lettuce and tomato (iceberg lettuce contains mostly water ? no nutrients).? Not worth it. Convenient, yes, but potentially cancer promoting.
- Make your own sandwich: Sprouted (Flour-less) bread, nitrite-free cold cuts of your choice, fresh tomatoes, romaine lettuce, goat cheese and a little mustard. All can be purchased in health-food stores. This is much better.
- Have lamb or sheep meat. They are lower in saturated fat and not grain-fed.
- Stay away from breaded meats ? once again flour and wheat are your enemy.
- Grilling and barbecuing is not a good option. ?These forms of cooking meats increases the likelihood of cancer causing HCA and PAH consumption. You can grill vegetables and portabello mushroom. Grilled portabello mushrooms (picture top right)? are delicious and ?meaty? in texture.
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Reference:
Daley CA, Abbott A, Doyle PS, Nader GA, Larson S. A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. Nutr J. 2010 Mar 10;9:10.
Zheng W, Lee SA. Well-done meat intake, heterocyclic amine exposure, and cancer risk. Nutr Cancer 2009; 61: 437?46
Richman EL, Stampfer MJ, Paciorek A, Broering JM, Carroll PR, Chan JM. Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression. Am J Clin Nutr 2010; 91: 712?21
Puangsombat K, Smith JS.Inhibition of heterocyclic amine formation in beef patties by ethanolic extracts of rosemary. J Food Sci. 2010 Mar;75(2):T40-7.
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Source: http://drgeo.com/red-meats-and-prostate-cancer-should-i-or-shouldnt
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Sunday, February 26, 2012
PFT: 3 catches, 3 TDs for T.O. in IFL debut
ReutersNearly six full days into the period for applying the franchise tag, no team has done it.? One league source suggested earlier this week that teams are holding off due to concerns that the players to be tagged haven?t been fully informed of the fact that this year?s franchise tenders will be considerably lower than last year?s numbers, given the new formula for calculating the amounts.
The theory is that the agents have yet to explain the situation to the players, hopeful that a long-term deal can be negotiated and/or that the team in question will decide not to use the tag on the player.? (In the case of Packers tight end Jermichael Finley, a two-year contract avoided a $4 million fight over whether he?s actually a tight end.)
But nine days remain before the tag window closes,? and Adam Schefter of ESPN reports that several specific players will have their ability to hit the open market limited by the tag.
They are:? Falcons cornerback Brent Grimes, Patriots receiver Wes Welker, Chiefs receiver Dwayne Bowe (pictured), Eagles receiver DeSean Jackson, 49ers safety Dashon Goldson, Cardinals defensive end Calais Cambpell, and Saints quarterback Drew Brees.
It?s widely believed that, if the Saints and Brees can work out a long-term deal, the Saints will use the franchise tag on guard Carl Nicks.
Schefter?s list of definites omits include several other prime candidates.? If the Ravens and running back Ray Rice don?t work out a long-term deal, Rice undoubtedly will be tagged.? Coach John Harbaugh essentially confirmed this at the Scouting Combine, saying that Rice will ?be making franchise-tag numbers, at least.?? Also, the Seahawks are expected to tag running back Marshawn Lynch, absent a long-term deal.? Ditto for the Bears and running back Matt Forte.
There are more.? It has been reported that the Redskins will tag tight end Fred Davis, notwithstanding his four-game suspension for smoking something that has more than four leaves.? Browns linebacker D?Qwell Jackson can expect the tag if he doesn?t do a new deal, and the Cowboys could decide to use the tag on linebacker Anthony Spencer.? There are conflicting reports on whether the Bills will use the tag on receiver Stevie Johnson.? The Lions are expected to tag defensive end Cliff Avril, if they can?t work out a new contract.
Kickers will get in on the action, too.? Matt Prater of the Broncos, Connor Barth of the Buccaneers, and Josh Scobee of the Jaguars are expected to be tagged absent new deals.
In Houston, tagging Mario Williams would result in a cap number that exceeds $21 million.? Thus, the Texas are more likely to use it, if at all, on running back Arian Foster, a restricted free agent who otherwise could be had for a single first-round pick.
Other possibilities remain.? Though it has been reported that the Packers aren?t likely to use the tag on quarterback Matt Flynn, the Packers can decide to pull a Matt Cassel with Aaron Rodgers? backup at any time before the deadline comes.? It also has been reported that the Chargers have told receiver Vincent Jackson that use of the tag is ?improbable.?
It?s not improbable that we?ll have plenty of additional stories regarding players who are or may be or won?t be or haven?t been tagged between now and March 5.
Source: http://profootballtalk.nbcsports.com/2012/02/25/two-catches-two-touchdowns-for-t-o/related/
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Ohio man given choice of Facebook apology or jail
CINCINNATI (AP) -- A man who was threatened with jail time for posting comments about his estranged wife on his personal Facebook page unless he posted daily apologies for a month says the court ruling violates his freedom of speech.
Mark Byron, who is making the apology to avoid 60 days in jail, said Friday night that he believes it's too late for him to appeal the domestic relations court ruling as planned. But the Cincinnati man and free speech and media experts say it should concern other users of the social networking site.
With hundreds of millions of people using Facebook for communication, Byron said that "if they can do this to me, they can do it to others."
The idea "that anybody could tell you what to say to your friends on Facebook should be scary to people," said Cincinnati attorney Jill Meyer, who specializes in free speech and media issues.
The ruling is highly unusual and "troubling because it's a court telling someone to say something to - in some regards - his chosen group of friends," said Meyer. She noted that the comments were not directed to Byron's wife, Elizabeth Byron, who was blocked from accessing the page.
According to the ruling, Byron posted comments on his page in November, saying in part, "If you are an evil, vindictive woman who wants to ruin your husband's life and take your son's father away from him completely - all you need to do is say you're scared of your husband or domestic partner and they'll take him away."
The Byrons are involved in ongoing divorce and child custody proceedings. Byron has said his wife and the court have prevented him from seeing his 17-month-old son many times. The court maintains he is allowed to see him on a twice-weekly basis.
Domestic Relations Magistrate Paul Meyers last month found Byron in contempt of a protective order because of his Facebook comments. Meyers said that Byron could avoid a 60-day jail sentence and a $500 fine by posting the apology - written by Meyers - to his wife and all of his Facebook friends and paying her attorney fees. The same apology must be posted every day no later than 9 a.m.
The June court order prohibited Byron from causing his wife physical or mental abuse, harassment or annoyance. She asked in December that he be found in contempt after learning of the Facebook comments.
Byron's comments expressed frustration, but they were not threats and he didn't make them to his wife, said Cincinnati attorney Jack Greiner, who also specializes in free speech and media issues.
Greiner said he doesn't think the First Amendment "allows a court to find that someone has harassed or caused a person to suffer mental abuse merely by expressing one's opinion about a court proceeding in a non-threatening way."
Greiner said that a court compelling speech through a court-written apology raises as many free speech concerns as actions prohibiting free speech.
The statement that Byron says he has been posting since Feb. 13 has him apologizing to his wife for "casting her in an unfavorable light" and to his Facebook friends for "attempting to mislead them. Byron said the apology forces him to make false statements.
The magistrate's assistant said Friday that Meyers cannot comment on pending court cases. Elizabeth Byron's attorney didn't immediately return calls.
The ruling says several of Mark Byron's comments were "clearly intended to be mentally abusive, harassing and annoying" to his wife and "generate a negative and venomous response toward her from his Facebook friends."
Responses by Facebook friends to his posting caused Elizabeth Byron to be "afraid and concerned," according to court documents.
Byron and his attorney, Becky Ford, say he made his comments out of frustration and never expected his wife to see them since she couldn't access his account.
"Once he made the comments, some of his Facebook friends started making inflammatory comments which he had no control over," Ford said.
His comments were "nothing other than free speech communication where he was venting truthful information," Ford said.
Bryon must appear in court March 19 and show proof that he posted the apology or face jail.
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Saturday, February 25, 2012
How Microsoft Kinect (Your Child's Xbox Accessory) Will Help Your ...
from your computer on March 6th - live from NYC.
My son loves his Microsoft Xbox. I love his Xbox too and challenge him in basketball frequently ? I?ve never won a game yet.
What is even more interesting for me and probably (much) less for him is Microsoft Kinect?for business.
Kinect is an accessoryfor the Xbox that adds voice, facial and body recognition to the Xbox experience.
Although hard core gamers salivate on the gaming experience, Microsoft is hoping that business owners will salivate on the business possibilities of using Kinect as a productivity enhancement.
Roy Chomko, President of web and app development firm Adage Technologies?said that he envisions a variety of technology embedded with Kinect. Imagine opening your notebook computer and having it recognize your face. I know there are already technologies like this, but using Kinect is new. Or taking this to another level, what about a virtual Kinect receptionist being able to great visitors are they come and go and in fact knowing who they are. Video conferencing is another opportunity for Kinect in business.
Read Write Web writes:
Ehrenberg outlined a scenario where workers on a warehouse floor or in a manufacturing plant are wearing safety gloves that make it difficult for them to operate computers and other systems that may be used to track inventory or confirm that certain steps in the manufacturing process are complete. Kinect?s motion-detection technology, he said, could be adapted to allow accurate input through a gesture which does not require glove removal.
So the next time you see Kinect in your office, don?t ask who?s playing games ? think business productivity.
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Diseases Multiple Sclerosis
MS is a disease that affects the central nervous system, which is made up by the brain and the spinal cord. As you probably know, the brain and spinal cord have a lot to do with how the body moves. So, MS will alter the way that someone moves.
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Multiple Sclerosis is a chronic, inflammatory disease of the central nervous system (CNS), which comprises of the brain and the spinal cord. You just walked out of your neurologist office after receiving the devastating news that you have Multiple Sclerosis. What now?
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If you?ve been diagnosed with Multiple Sclerosis your doctor has likely explained the science of the disease, and that you are in for a long haul of treatment plans and discomfort. I strongly believe that a fitness program that works on all aspects of your fitness (such as strength, balance, flexibility, co-ordination, breathing and cardio) can only be beneficial for you.
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Multiple Sclerosis treatments focus on battling the autoimmune response and managing symptoms of MS.
Treatments include medications,It would appear that patients with relapsing-remitting multiple sclerosis will soon be offered two new oral medications.
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There was a story last night on our local news about a woman with multiple sclerosis who has regained her ability to walk because of a new oral medication.Multiple Sclerosis, or MS, is a disease that usually appears in adults between the ages of 20-40. MS occurs when the brain and spinal cord sheaths incur damage
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Multiple sclerosis affects the nervous system, and inhibits the brain from communicating with other nerve cells. When someone develops MS their immune system attacks its own body.
Multiple Sclerosis or MS is a nerve cell disorder that affects the brain and the spinal cord, which controls all the physical activities of the human body.
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Multiple sclerosis is a condition in which the capacity of the nerve cells in the spinal cord and brain communicate with each other is diminished. Neurological disorders, as the name implies, affect the entire nervous system i.e. the central nervous system, the peripheral nervous system and the autonomic nervous system.
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There are many conditions and diseases in that may qualify Americans to obtain disability payments from the Social Security Administration, or SSA.Many studies have shown that sleep disturbances, in folks with MS, are 3 times more common than in the general population.
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Read abo ut design competition and also read about harvard business school and master of business administration
Source: http://www.a1article.net/health-and-fitness/diseases-multiple-sclerosis-4894.html
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Friday, February 24, 2012
Advice Career Change Teacher | Career Organizing.com
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AP Interview: Oscar nominee Demian Bichir (AP)
[unable to retrieve full-text content]AP - Demian Bichir learned an important lesson when he left his native Mexico to launch a U.S. acting career and ended up working in a Mexican restaurant in New York: How to live the invisible life of an illegal immigrant with dignity.
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Thursday, February 23, 2012
Pawnshops for prosperous accept wine as collateral (Reuters)
[unable to retrieve full-text content]
Reuters - literally.
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Learn These Straightforward Simple Steps For Home Improvement ...
Depending on how you approach it, renovation might be a real headache, or it can be just what?s wanted to make your house a home. After reading these tips, you?ll have some fresh concepts to draw on when you begin a new project. You may be successful at do-it-yourself by implementing these ideas.
Take care to confirm that your contractor has listened to your instructions. Having a trusty contractor is incredibly important, but so too is making absolutely sure that they hear your worries. If you do not get your contractor?s attention and confirm they understand what you want, the contractor can accidentally make a mistake. Ensure your contractor listens to you and your needs.
Motion detecting lights add exterior visibility without accelerating your electrical bill. Motion turned on lights add that extra bit of security, because they can shock a potential thief, and the light will warn you of their presence. Motion sensitive lights are highly effective when it comes down to lowering your electrical bill. This is thanks to the fact that the lights, and therefore electricity, are only being used when required.
If you would like to display your jewelery, you need to use a straight coat rack. Don't display your high-priced or irreplaceable jewellery. Hanging up jewellery like this not only improves a room?s appearance, it keeps your necklaces freed from tangles, too. Keep a few pieces in a simple to access location.
Force on the bristles leads them to bend, which may wear them out faster. Hanging the brush up will answer this problem, increasing the life of your brush. The same principle is correct for mops. The increased concern for a mop is to make allowance for drying to reduce the amount of bacterial growth.
Turn off water if you're doing kitchen or rest room do-it-yourself projects. Make sure you know where the shutoff valve is for your water pipes so you don't have a flooding problem when you start the project. Taking this step helps to prevent flooding.
Create a visually pleasing bookshelf with the utilization of some wallpaper. Select a fun and original wallpaper design. Paste the wallpaper onto the interior of the bookcase to give your favourite books a fashionable background. Not merely will this bring an old book shelf back to life, it's going to be a signature piece in your room.
Before winter gets here, take the time to insulate your pipes. Weatherizing tape, which you apply to your pipes, can be found at most home improvement stores. This way, you can stop accidents due to frozen or burst pipes.
Keep an eye out for patches of ground that are lower than their surroundings, and pay particular attention to the ground near your foundation. These areas should be stuffed with compressed soil to stop water from pooling and eroding parts of your yard. If water pools up near your place, it can eat at the bedrock of your home.
Stucco is an enticing replacement option for your exterior siding. Stucco is comparatively straightforward to install compared to wood or vinyl siding. Once it is installed, it will last a good number of years also.
When considering home improvements for areas with plumbing, like the kitchen and lavatory, consider replacing the walls with something more waterproof. Water resistance is necessary to forestall threatening molds from flourishing within clammy walls. ?Green board? is a product that is resistant to water, and can forestall mould expansion so is excellent for this reason.
Many folks are unaware of all the stuff that really must be considered in home improvement. There's a lot of work involved, but the ultimate result is almost always worthwhile. When you employ the tips mention here, you can tackle those renovation projects in almost no time.
These renovation tips are brought straight to you by the leader in AC Mend Tampa service. Call Air-con Tampa if you have questions on any of these home improvement tips.
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Wednesday, February 22, 2012
[BANNED] Ban Report: Mack and chingchowbow (Spamming and ...
Code:
Asus G74SX-DH71 (Custom Build) Processor: 2nd Gen Intel Core i7-2960XM Extreme, 2.7-3.7GHz, 32nm, 8MB, 55W Memory: 14GB DDR3 1333 Dual-Channel (2G X 1 + 4GB x 3) Optical Drive: 6X Blu-Ray Re-Writer/8X DVDRW Super Multi Combo Drive Hard Drive: - Primary: 500GB Seagate Momentus XT 7200RPM 32MB, 4GB SSD Hybrid Drive, SATA II 3Gb/s - Secondary: 750GB 7200rpm SATA II 16MB 3GB/s (Standard) Video Card: nVidia GeForce GTX 560M 3GB GDDR5, DX11 Thermal Compound: IC Diamond 24 Carat Thermal Compound on both CPU/GPU HDMI: HDMI 1.4, 60Hz/120Hz output 1080P, 3D Ready Wifi: Intel Advanced-N 6230 Wireless-N + Bluetooth Combo Card USB: 3 X USB 2.0, 1 X USB 3.0 Port 4.8 Gb/s Webcam: Built-in 2.0 MP Webcam Headset: Razer Megalodon 7.1 Surround Sound Gaming Headset Mouse: Logitch MX Revolution Operating System: Windows 7 Home Premium - 64bit Screen: 17.3" 16:9 1920X1080 Full HD LED backlight Ultra Bright, 72% NTSC Color Gamut, Anti-Glare
Source: http://hellsgamers.com/threads/62682-Ban-Report-Mack-and-chingchowbow-(Spamming-and-racism)
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Blocking telomerase kills cancer cells but provokes resistance, progression
ScienceDaily (Feb. 20, 2012) ? Inhibiting telomerase, an enzyme that rescues malignant cells from destruction by extending the protective caps on the ends of chromosomes, kills tumor cells but also triggers resistance pathways that allow cancer to survive and spread, scientists report in the Feb. 17 issue of Cell.
"Telomerase is overexpressed in many advanced cancers, but assessing its potential as a therapeutic target requires us to understand what it does and how it does it," said senior author Ronald DePinho, M.D., president of The University of Texas MD Anderson Cancer Center.
"We exploited the experimental merits of mice to model and study more precisely telomere crisis, telomerase reactivation and telomerase extinction in cancer development, progression and treatment," DePinho said. "This elegant model exposed two mechanisms, including one unexpected metabolic pathway, used by cancer cells to adapt to loss of telomerase.
"These findings allow us to anticipate how tumor cells might respond to telomerase inhibition and highlight the need to develop drug combinations that target telomerase and these adaptive resistance mechanisms," DePinho said.
Researchers evaluated telomerase as a therapeutic target in experiments that originated in DePinho's lab at the Dana-Farber Cancer Institute in Boston. He became MD Anderson's fourth full-time president in September.
Telomerase activity is low or absent in normal cells, which have segments of repeat nucleotides called telomeres at the ends of their chromosomes that protect DNA stability during cell division, said first author Jian Hu, Ph.D., an instructor in MD Anderson's Department of Cancer Biology.
With each division the telomeres shorten, leading eventually to genomic instability and cell death, a period termed "telomere crisis," Hu said. In cancer, telomerase becomes active during telomere crisis and rescues the genomically abnormal cells by lengthening telomeres.
In a series of experiments in a lymphoma mouse model, the team found:
- Telomerase reactivation in malignant cells after genomic instability causes cancer progression.
- Inhibiting telomerase caused tumor cell death but also led to alternative lengthening of telomeres (ALT) independent of telomerase.
- ALT-positive cells increase both the expression and copy number of a gene called PGC-1?, a key regulator of mitochondrial function, to compensate for mitochondrial and reactive oxygen species defense deficiencies.
- Targeting PGC-1? to weaken mitochondria function enhances anti-telomerase therapy.
To study the impact of reactivated telomerase, DePinho and colleagues genetically modified mice to develop T cell lymphomas and to have telomerase reactivated when the mice are treated with 4-hydroxytamoxifen (4-OHT). They crossed the mice for several generations, treating some with 4-OHT and others with a control vehicle that did not trigger TERT activation.
Telomerase reactivation causes aggressive cancer
Third- and fourth-generation mice with telomerase activated by 4-OHT had a median survival of 30 days and more frequent tumor infiltration to the spleen, kidney, liver, lung, bone marrow and brain than did control-treated mice, 70 percent of which lived beyond 50 days. Tumor cells in control-treated mice were more likely to be detected and destroyed by tumor-suppressing p53 signaling.
"These findings are consistent with telomere crisis leading to genomic instability during early stage cancer, with reactivated telomerase protecting malignant cells later to ensure tumor progression," Hu said.
Telomere dysfunction causes cancer-promoting genetic changes
Later-generation mice with activated telomerase had 4,928 amplified genes and 2,297 deletions. The team compared these changes to those in human lymphoma tumors and found 565 matching amplified genes and 300 deletions.
These cross-species copy number alterations included several known tumor-suppressing genes and oncogenes, suggesting that initial telomere dysfunction not only drives primary tumor development but also confers malignant traits such as invasiveness.
Telomerase extinction works -- at first
The team then took tumor cells from late-generation mice with activated telomerase -- the aggressive tumors -- and passaged them four times through groups of mice treated with either 4-OHT to trigger telomerase production or the control vehicle that leaves the enzyme off.
During the first two rounds, survival for the two groups was about the same. In the third round, the control mice had a major improvement in survival over the telomerase arm, indicating that telomere erosion had allowed cellular defense mechanisms to pick off genomically unstable cells.
However, in the fourth passage, survival of the control-treated mice fell back toward that of mice with active telomerase. The tumors had become resistant without relying on telomerase.
Alternative lengthening of telomeres rescues cancer cells
An analysis showed that telomere lengths of tumor cells with active telomerase remained largely unchanged across the four passages. Telomeres shortened in cells lacking telomerase through the first two passages followed by a sharp increase during the third and fourth passages.
Other molecular evidence pointed to alternative lengthening of telomeres in telomerase-absent cells.
They found that ALT-positive tumors had different gene expression patterns -- 891 genes with increased expression, 1,345 with decreased -- compared to telomerase-positive tumors.
Key gene in mitochondrial pathway active in ALT cells
Many genes were found in networks regulating mitochondrial biology and oxidative stress regulation. PGC-1? was the only gene in both pathways with increased expression and copy number gain in the ALT-positive tumors.
PGC-1? is a master regulator of both pathways, which turn out to be dysfunctional in ALT-positive tumors. When the researchers knocked down PGC-1?, mice with ALT-positive tumors survived much longer than those with intact PGC-1? and than those with activated telomerase in their tumors.
In normal cells, power-generating mitochondria process fatty acids to produce ATP, a molecule that serves as the major energy source for the cell. Cancer cells generally rely more on sugar processing to generate energy. However, DePinho and colleagues note their genetic evidence suggests that mitochondria play a role supporting cancer cells.
This research was funded by grants from the National Cancer Institute, the Leukemia and Lymphoma Society, the Fundaci?n Ram?n Areces, and Helen Hay Whitney Fellowship, the Ellison Foundation for Medical Research and the American Cancer Society.
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The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center, via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Jian Hu, Soyoon?Sarah Hwang, Marc Liesa, Boyi Gan, Ergun Sahin, Mariela Jaskelioff, Zhihu Ding, Haoqiang Ying, Adam?T. Boutin, Hailei Zhang, Shawn Johnson, Elena Ivanova, Maria Kost-Alimova, Alexei Protopopov, Yaoqi?Alan Wang, Orian?S. Shirihai, Lynda Chin, Ronald?A. DePinho. Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer. Cell, 2012; 148 (4): 651 DOI: 10.1016/j.cell.2011.12.028
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/02/120220161229.htm
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Thursday, February 9, 2012
Market News: Analysts Say Now May be the Best Time for Greek ...
No one really wants to see Greece go under, but if the country has to default on its debt, there may be no time like the present ? literally ? say global investment analysts. Citigroup credit analyst Jason Shoup described the situation, saying that ?in the last six months, there?s probably been no better time to let Greece strategically default than right now.? Shoup cited last week?s positive recovery theme, pointing out that 15 of 23 recovery indicators beat expectations and that some economists even raised their growth outlooks for the full year[1]. In light of all this enthusiasm and arguably ?startling jobs growth? in the U.S., maybe now is the time to bite the bullet, he said.
Of course, where Greece goes, other nations are likely to follow. Many experts believe that Portugal will likely fall shortly after Greece, although some ? like Portugal?s prime minister ? do insist that the nation?s debt load is sustainable and has promised publicly that ?we will not allow what happened in Greece to happen here.? The prime minister compared Portugal?s debt profile to that of Ireland, which has been recovering ? sort of ? in the face of austerity measures adopted in order to meet bailout requirements[2].
Do you think that Greece should default? Is this even an option that should be considered?
Thank you for reading the Bryan Ellis Investing Letter!
Your comments and questions are welcomed below.
[1] http://www.cnbc.com/id/46281928
[2] http://www.reuters.com/article/2012/02/06/portugal-debt-idUSL5E8D63KB20120206
Category: Financial Markets
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Wednesday, February 8, 2012
Nikon confirms 36.3 megapixel D800, we go hands-on
Continue reading Nikon confirms 36.3 megapixel D800, we go hands-on
Nikon confirms 36.3 megapixel D800, we go hands-on originally appeared on Engadget on Mon, 06 Feb 2012 23:01:00 EDT. Please see our terms for use of feeds.
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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ZWNGEfRbIes/
Tuesday, February 7, 2012
Arts and entertainment calendar for Feb. 9 | ThePhotoTimes.com
[unable to retrieve full-text content]Arts and entertainment calendar for Feb. 9. Updated: February 6, 2012 6:50PM .... 10-12 at the College of Lake County's James Lumber Center for the Performing Arts, 19351 W. Washington, Grayslake. Performances are at 9:30 a.m., 11:45 ...
Source: http://thephototimes.com/arts-and-entertainment-calendar-for-feb-9/
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How Would You React If You Were Diagnosed With Skin Cancer ...
In addition, people who smoke are at a significantly higher risk for skin cancer than nonsmokers. By now you?ve heard that skin cancer is the most frequent form of cancer in the U. Skin cancer is only one of the many cancers that can be induced from smoking and alcohol use. These can at times appear alarming to the untrained eye but clearly show a ?greasy?, stuck on look with some characteristic attributes such as a ?warty? surface, pseudofollicular openings and milia-like cysts. Understand self-examination of skin cancer, as a way to defend yourself, that is effortless and costs you nothing at all a lot more than a couple of minutes of your time as soon as every couple of months. If it is cancer, it will form a little puss circle about the spot. Tanning itself takes place in the skin?s outermost layer, the epidermis. If this happens, consult your physician immediately. If there is a history of melanoma in your family members, you are at a higher risk for skin cancer. I noticed that when I applied it, it stung actually negative, but only on the wound site and not on the surrounding skin, so I researched this and was comforted to know that it only kills the cancerous cells, not the healthy skin cells, so this explained why it left the healthy surrounding skin unaffected. This most current investigation involved examining the effects of drinking coffee on skin cancer risk for over 110,000 subjects who took portion in two big scientific studies. On typical, about 20 years of life are lost for every melanoma death in the UK. Pick sun protective put on, including swimwear, when you are enjoying the beach or lakeside. When you begin regularly seeking and examining your marks, you will be in a position to see in seconds if anything changed. When most people hear their physician say the word ?cancer?, they know that it really is a copycat recipes olive garden copycat recipes serious wellness problem and will be hard to deal with.
Let?s talk about this today simply because whenever we mention the word ?cancer? a fear comes over us and we panic or are scared to pieces of the end outcomes. copycat recipes Nothing at all is as valued as life, so if you can avoid a deadly disease why would not you. A for asymmetry ? not even on all sides, B for Borders, C for color, D for diameter and E for evolving. Smoking, alcohol, and poor oral hygiene are also believed to boost the risk of this condition. We now await future clinical trials on turmeric and skin cancer in both humans and animals, typically in mice. Think of the letter ?A? for asymmetry. What actually causes skin cancer. Likewise, it should not be too tilted onto any one side. Summer is a time for swimming, outings, picnics, and fun. People that operate in chemical plants or about chemical substances are significantly a lot more most likely to get skin cancer. Squamous occurs in the top level of the skin, basal cell in the middle layer of the skin and melanoma in the deep layers of the skin. It should be noted that sunscreens absorb UV light, therefore stopping the radiation from penetrating the skin. They are Asymmetry, Border, Color, Diameter and Elevation of the moles or skin growth. Spending a lot of time outside with no taking precautions can lead to wellness troubles. The symptoms for the basal cell skin cancer are that it develops some scaly surface on the area which is usually exposed in the light. I?ll let you know a lot more when I know a lot more. More than 9,000 people died from it. Basal cell carcinoma might spread to tissues about the cancer. It is obtaining higher possibility to get this cancer immediately after 1970s.
They reported a number of successes, with the tumor falling off within days or weeks. Early detection of skin cancer is extremely essential. I was asked the other day, do skin cancer cells come back years later. Do you have a lot more than 50 moles on your body or do you have a history of sunburns. They are even a lot more essential than even with the quantity of processed foods we consume.
It was identified in a current investigation that people with Parkinson?s had a higher risk of developing melanoma. I have noticed considerable positive aspects from using it and also really feel good from understanding that I have the prospective to benefit from turmeric and skin cancer prevention.
But the UV rays of the sun do percolate or filter by means of even the cloud cover, which can lead to a sun burn on an ostensibly cloudy day. Get it checked by a Medical Skilled. Individuals with a history of melanoma would be advised to look at their SPF 60 sunblock cream. Sadly, the positive aspects of tanning beds do have their disadvantages. The ultraviolet ray coming out of these heat lamps (UV-A rays) can simply penetrate in to the skin deeper as compared to UV-B rays that come from sunlight. There are three fundamental sorts of skin cancer:
Actinic Keratosis: A crusty or scaly spot that can grow to be cancer. What would typically look like an ordinary mole (smaller than 6mm, even color and shape, flat) on yet another portion of the body like your arm, face, or torso, can be one thing like melanoma if on the soul of your foot. Throughout 2009 according to the newest figures from researchers who reported last year that 2 million people in America had been treated for 3. My family members all had skin cancer. Some portion of the upper chest and upper back also get affected by this condition. Skin cancer starts in the epidermis or the outermost portion of the skin which is formed by three sorts of cells ? the squamous, basal and melanocytes.
Source: http://hurleysaudio.com/how-would-you-react-if-you-were-diagnosed-with-skin-cancer/1500/
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Monday, February 6, 2012
Health and Fitness Articles ? Blog Archive ? Home Health Care: Is It ...
Home health care? Do you have a disabled person in your family or life who could benefit from the daily service of home health care providers ? Or an elderly family member who requires senior care? With the average family in the United States being unable to pay their own health care costs, let alone the costs of their other family who might have specific health care needs, the option of utilizing a home health care or hospice providers is becoming an increasingly popular one. Have you looked into the benefits of using a trusted home health agency or home health care service to help care for the needs of those you love who cannot take care of their own health care needs? If so, then Salt Lake City Home Health Care might be one of the best care providers that you should look into.
What does a Salt Lake City Home Health Care Do?
For most, the biggest part of choosing a health care agency and deciding between home health care services is knowing what their family member of loved one will be helped with if they were a patient with that agency. Basically, a hospice or home health care provider from an agency will either assist a medical professional, such as a nurse, with daily duties, or act as an aid and perform them herself. Some of these health care duties include, but are not limited to:
- Tracking basic health and health care stats
? Caregivers administering medicine(s) when applicable
? Tracking temperature, heart rate, etc.
? Assist in basic rehabilitation health care needs, such as taking a short walk with the patient, etc.
? Establish a relationship of trust and friendship between the caregivers or nursing staff and patient as well as their family
? Help with basic , non medical daily tasks involving senior care
? Establish a basic exercise regiment that is implemented and carried out in home health care ? particularly with senior care.
The Purpose of Home Health Care
The purpose of home health care agencies and Salt Lake City Home Health Care in particular is to be alongside their patients and meet home health care needs. Knowing the medical and non medical home health care services of care agencies can help you choose the home health care and caregivers that are right for your family. There are various caregivers and agencies in the home health care arena that can help with your family and your needs.
Domiciliary Care in Home Health Care
This type of health care is for patients who can?t live alone but do not need the 24/7 care of a nursing agency, hospice, or other home health care agencies. They live under the supervision and assistance of care providers and nursing staff to deal with specific medical and health needs. A variety of agencies and home health care providers in the United States offer domiciliary care in home-like settings.
Senior Care and Hospice Care in Home Health Care
If your family member is in the stage of life where they need the help of nursing staff or other home health care providers to assist with daily activities , Salt Lake City Home Health Care is there for them. The same applies to individuals who may have a short life expectancy for any reason and require hospice home health care and specialized nursing. Home health care agencies specialize in making the transition to death an easier one for both the family and the patient. Call Salt Lake City Home Health Care today, and make life better for your family! Basics of Home Health Care
For most, the biggest part of choosing a health care agency and deciding between home health care services is knowing what their family member of loved one will be helped with if?. Learn more at SLC Home Health Care and care agencies
Tags: Health and Fitness, Salt Lake City Home Health Care
Source: http://www.healthandfitnessarticlesblog.com/home-health-care-is-it-right-for-your-family/
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Sunday, February 5, 2012
Volunteer at the Yawkey Family Inn at Children's Hospital Boston ...
5th February 2012
To guarantee the best treatment for their sick children, patient families will travel from across the globe to Children?s Hospital Boston. Many of these families arrive in Boston with just the clothes on their backs and no temporary living arrangements. Newly renovated, named and opened, the Yawkey Family Inn (YFI) is just blocks from the hospital and doubles the amount of affordable housing available to Children?s families. With 22 bedrooms, shared bathrooms, a fully equipped kitchen and common areas, the YFI offers all of the comforts of home to families during their greatest time of need.
This house was made possible, in large part, by the Yawkey Foundations, which awarded a $3 million gift to support the new home. Additionally, the Family Inn Foundation, a long-term partner of the Yawkey Foundations, generously donated its independently operated Family Inn on Sewall Avenue to the hospital. Created 25 years ago with the support of Jean Yawkey, the Family Inn has provided much needed accommodation for out-of-town patient families.
Last year, the New England Revolution and Major League Soccer donated a greenhouse to Children?s Yawkey Family Inn, bringing sunshine to families who?ve traveled far from home for their child?s care. The staff is looking for volunteers with green thumbs to help keep this space bright. An experienced gardener or gardeners must assess the required needs of the greenhouse, including maintenance, then schedule seasonal plantings, while giving tips to the program staff regarding continued maintenance of the greenhouse, which is located at 241 Kent Street in Brookline. If you are interested, please contact Sharon Healey at 617-919-3455.
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Free health insurance & pension benefits for public employees ...
Uh oh?.looks like someone needs to read something other than Scott Walker talking points?
Here?s a question ? Why should you get your health insurance and pension for free? What makes you so special?
The ?you? Randy Hollenbeck is referring to would be Wisconsin?s public employees.
What?s curious is that I?ve been a public employee for over ten years, and I can?t remember a time where I?ve ever had my health insurance and pension benefits provided to me for free. In fact, the share of my health insurance and pension benefits that I?ve had to pay has steadily risen every year I?ve been a public employee, while my wages have stagnated, failing to keep up with increases in the cost of living. Obviously I can?t speak to whether or not there may have been some public employees who received free health insurance and pension benefits, but the vast majority of public employees that I know have never had free health insurance and pension benefits.
Later in his blog entry, Hollenbeck doubles down on the Republican talking points, saying,
?Furthermore, we will need to offload part of the burden of YOUR benefits off the backs of the taxpayers so you will have to pay a small portion yourself!?.
To borrow a line from Randy Hollenbeck, ?Anti-intellectuals are always demonstrating how desperately they need to invent their own demons to throw stones at,? and in Randy?s case his demons seem to be public employees.
Source: http://bloggingblue.com/2012/02/04/free-health-insurance-pension-benefits-for-public-employees/
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Saturday, February 4, 2012
Open Channels For Conversing Are Imperative To Any Marriage ...
When people are told that they need to communicate more they often think that is an open invitation to talk but there is a complete difference between talking and communicating.
The first thing we must realize is that effective communication is a skill set. It can be learned. So for those with poor communication skills, there is hope. It is all about talking to people in a way in which they do not feel threatened or defensive but feel like you have their back.
I would challenge you to take time and go to the mall and watch the people around you and see how they talk to each other and the way in which they communicate. What I find disappointing is the fact that there are many, many great opportunities to connect that are missed because so often we don?t know how to positively communicate with each other and therefore we loose touch with each other?s emotions.
One thing we must all agree on is that we make things so much harder when we do not listen to our spouse the way that they need us to listen to them. It is important to always take the temperature of how you are feeling. It is okay to take a few minutes to relax if you become frustrated.
Over the years it?s amazing the number of times people are provided with information that, if they acted upon, could totally alter a relationship, career or the success of a business. But, because the sheer lack of peoples ability to listen to and think through another persons point of view unique opportunities pass them by.
Remember the fact that the love quotes that people all read should be a motivation rather than a indictment. We all all want a commitment which endures just like we learn about within the quotes about love. Nonetheless that relationship is one that is certainly acquired and not just given to us.
Interestingly enough, a good relationship is a lot like a working partnership. Often, what could be a marriage made in heaven is destroyed by the sheer inability to communicate. The most successful relationships, be it business or personnel are those whereby both parties have strong verbal and listening skills.
Sad to say, a lot of marriages start out on the wrong foot of listening skills. |Unfortunately, so many relationships begin with dysfunction with talking to each other. Why is it that we feel like our spouse should know what we are feeling and thinking? It is our job to clearly communicate how we feel and what is our needs so that our partner understands.
How many people decide not to tell their partner something just because they don?t know how to say it and then the problem just eats away at the relationship until there is no relationship left? The sad thing is that if they would just learn to let go of their anger they could begin to build a relationship based on love and mutual respect.
Source: http://www.zunelist.com/?p=21734
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Free Make Money From Home Business ? Part 1 | How Can I Find ...
Two-part video shows how to make money online with affiliate marketing with the largest digital marketplace online today. This is probably the most honest and unbiased series on YouTube explaining how to get started with affiliate marketing without spending any money. Post whether or not this helped you get started. NOTE: My videos keep getting corrupted during YouTube conversion? Go to www.clickbankcommander.com to watch the videos without the audio/video sync errors and without 2-3 minutes cut off the end of each YouTube video 
www.lovenormoney.com Many people today are shedding the corporate world and working from home. With the cost of childcare, the rising gas prices, and the need for parents to connect with their children more often, working at home has become more popular in the last decade. Many people are participating in online surveys to make money at home. There are hundreds of online survey sites who need your opinion on a variety of topics, and they will pay you to fill out surveys. This video series is filled with information on how you can get your share of cash from filling out paid surveys on the internet. You will learn how to find the best paid survey sites, how to get started, how much money you will make and so much more. tags: best free paid online surveys free paid surveys make money doing surveys online surveys for cash best paid surveys highest paid surveys paid surveys review paid surveys reviews paid surveys etc paid surveys paid surveys online The Best Free Online Paid Surveys Click here ? www.lovenormoney.com
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Source: http://howcanifindmoney.net/free-make-money-from-home-business-part-1/
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Friday, February 3, 2012
Review: SOL: Exodus (PC) | Video Game News & Reviews - Bits 'n ...
Posted by Chad M. on Friday, February 3, 2012 ? Leave a Comment?
Fleet Action
The golden age of the space combat sim is behind us- we?re probably not going to see a resurrection of TIE Fighter or Wing Commander anytime soon. However, there are still developers out there keeping of the dreams of starfighting glory alive. One of those developers is Seamless Entertainment, who have recently released their take on the classic genre.
Set in a far future when Earth?s sun is burning out, SOL: Exodus puts you in the cockpit of a United Colonies of SOL fighter as you lead the remnants of the UCS ?military forces against the Children of Dawn, an army of militant religious zealots bent on wiping out anyone who doesn?t embrace the destruction imminent in the dying sun. As you lead the eponymous Exodus, the CoD forces will harry you and make your life miserable every step of the way.
The gameplay is fairly easy to pick up, and falls on the more arcade-ish side of the space sim spectrum, lacking complexities like subsystem damage or customizable loadouts. Still, the game doesn?t do all the work for you, and you?ll have to pull some fancy flight maneuvers, hack transmission nodes on enemy vessels, and switch between targets on the fly, as well as keep steady aim (enemy gunships make sure that your missiles can?t do all the work). The hacking mechanic is well implemented, forcing you to target a hack point, then watch for the code that appears and then select the code. This can have cool effects like turning missiles against your enemies or revealing the ship?s weak points- however, you can only do it at certain scripted points and can?t, say, take out the frigates in the tutorial with it.
The game doesn?t offer you a choice of fighters, offering only the standard Hades starfighter, but this is justified by being part of a ragtag remnant fleet. Your ship is adequately equipped with a pair of automatic guns, a hard-hitting energy weapon called the MAG cannon, and a complement of guided missiles (which were unfortunately nerfed a bit in the last patch so you can?t really ?Fire and forget? anymore). The enemy fleet has a bigger variety of ships, ranging from cannon fodder fighters to upgraded gunships and elite fighters, as well as capital ships and the specialized ADD, which is like a robotic leech that attaches to your own capships and transports.
The controls for the game are fully customizable, and I used my joystick/throttle setup (a Thrustmaster T.Flight Hotas X) through the campaign, which played without a problem. I also replayed the tutorial with the Xbox 360 gamepad, which also played smoothly and was easy enough to get into. The game also gives you the option to play with mouse and keyboard, but I?d recommend a stick or, if you don?t have a joystick available, a gamepad.
The game features 8 missions including the prologue/tutorial, with a decent variety of objectives in each, although many of them boil down to ?protect the Atlas? (your home base/carrier) and ?destroy the enemy capship?. There are usually secondary objectives which, when accomplished, will add to your mission score and possibly net you bonuses that can be used to upgrade your fighter (although some of the later mission challenges are daunting). There are also a few missions which are less about defense and more about pure dogfighting, and I have to admit that these were my personal favorites.
Graphically, the game is competent and often colorful, although as it uses the Unreal engine it is occasionally prone to texture pop-in. They mostly stay smooth at full settings (with the exception of the final mission in early releases, although this has since been remedied with a patch.). The fighters and capships all have interesting designs, and I particularly love the launch deck, which is reminiscent of the Viper launch sequences in the original Battlestar Galactica series. The character portraits are also quite good, with the UCS all having a military bearing, the sole civilian having a professionsl appearance, and the CoD all looking appropriately insane.
The sound effects are what you would expect. No, sound doesn?t travel in space in reality. Willing suspension of disbelief applies here as in most science fiction. Of course, the game would seem a lot less lively without the whoosh of afterburners, the electric splash of the MAG cannon and the beep of the incoming missile indicator. In addition, the voices are very well done and fit the characters well, with special note to the deliciously hammy Children of Dawn commanders. Their frequent proclamations of your impending doom fit their villainy well, and make for some fun bad guys.
The initial release of the game was riddled with bugs and balance issues, but the Seamless crew have been active on the Steam forums, and more importantly have been listening to user concerns (including some of my own issues with framerate in the final mission, which were resolved in the 02/01 patch). The team has shown that they?re willing to make the game more user friendly- refining the tutorial to make it a more comprehensive example of how to fly and fight, as well as dealing with issues regarding the hacking feature.
The Final Verdict
The game is not the second coming of Wing Commander or Freespace, and coming from a small independent team I don?t know why so many are expecting something of this magnitude. It?s a rather short game, with only 8 missions in the campaign (clocking in at 6 hours for me), although you can go back to reply any mission after you?ve completed it. It offers a nice challenge for newcomers to the genre and a fun diversion for veterans. It?s not perfect, but it?s a genuinely good game made by a team with some serious love for sci-fi space combat. At $9.99 USD, SOL: Exodus is definitely worth checking out.
Source: http://bnbgaming.com/2012/02/03/review-sol-exodus-pc/
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